CloSYS vs. Chlorhexidine

A New Standard

Recent testing shows that Rowpar Pharmaceuticals' CloSYS oral rinse compares to chlorhexidine (CHX) in many key aspects of post- procedure oral hygiene.

CloSYS was shown to have robust performance comparable to or better than CHX in killing oral bacteria. Unlike CHX, CloSYS does not interfere with fibroblasts, which are associated with the healing process. This distinction, reported by Dr. Robert Wirthlin, DDS, supports CloSYS's benefit in facilitating the healing process. Patients demonstrate noticeably improved oral health within a few weeks of making the rinse part of their daily routine.

Laboratory Results

The study conducted by David Drake, M.S., Ph.D., Professor of Microbiology and Director of Research in the Department of Endodontics at the University of Iowa, compared bactericidal activity of the CloSYS rinse to that of CHX (Peridex®). Each oral rinse was tested against a select group of bacteria known to be associated with periodontal disease and dental caries. In carefully standardized conditions, the rinses were introduced to the individual bacterial strains and the effectiveness in combating these periodontal pathogens was measured.

The kill rate for CloSYS surpassed that of CHX in the first minute for Actinomyces naeslundii (involved in periodontal disease and endodontic infections) and Peptostreptococcus micros (found in periodontal disease). The kill rate for Streptococcus mutans (causes caries) and Actinomyces viscosus (involved with oral infections) were higher for CHX in a first minute sample, but by five minutes, CloSYS and CHX samples proved identical at 100% kill rates. With Porphyromonas gingivalis (culpable in the progression of chronic periodontitis), Actinobacillus actinomycetemcomitans (causes localized aggressive periodontitis), Actinomyces odontolyticus (responsible for deep dental caries and chronic periodontitis) and Prevotella nigrescens (found in endodontic infections), both CloSYS and CHX achieved a 100% kill rate in the first minute.

CloSYS was also observed to exceed bactericidal properties against staphylococcus aureus, which is not necessarily an oral pathogen, but is the causative agent of staph infections. CloSYS exhibited 100% kill rate within the first minute of exposure.

Performance Plus

With its strong performance against the oral bacteria that cause infections of the periodontium and endodontium, as well as dental caries and staph infections, and its favorable behavior toward healing cells (fibroblasts), CloSYS addresses a spectrum of clinical oral hygiene concerns. Finally, its agreeable taste and non-tooth-staining characteristics-especially coupled with its lower cost and over-the-counter convenience compared to its prescription counterpart-encourage patients to be fully compliant. As a non-prescription oral rinse, CloSYS not only meets and may surpass CHX in post-procedure applications, it also can be recommended for twice-daily regular oral care as a maintenance and preventative measure. CloSYS is now a premium standard for daily oral care.

M. Robert Wirthlin, DDS, Brand J AHN, DDS, Belma Enriquez, BS, and M. Zamirul Hussain, PhD. Effects of stabilized chlorine dioxide and chlorhexidine mouthrinses in in vitro cells involved in periodontal healing. Periodontal Abstracts, The Journal of the Western Society of Periodontology, vol. 54, no. 3, 2006.
David Drake, MS, PhD. Alissa L. Villhauer, BS, Dows Institute for Dental Research, College of Dentistry, University of Iowa An In Vitro Comparative Study Determining Bactericidal Activity of Stabilized Chlorine Dioxide and Other Oral Rinses Journal Clin Dent 2011;22:1-5